Category: News

“Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC-β4 loop insertion mutations” has published online at: www.pnas.org.

Congratulations David!

Valerie Flint has successfully defended her dissertation, “SHIELD: Snv Heuristic Identification, Exploration, and Location Detector.”

Congratulation Dr. Flint!!!!

Ruan Zheng has successfully defended his dissertation, “Functional annotation of oncogenic mutations in epidermal growth factor receptor kinase.”  During his tenure with IOB, Ruan completed an astonishing eleven publications!

Congratulations Dr. Zheng!

April 25, 2018:  IOB graduate students Liang-Chin Huang and Ruan Zheng in Dr. Kannan’s lab have recently published a paper in Scientific Reports. By integrating protein-related data from multiple sources, their work explored current knowledge gaps in the relationships connecting kinome cancer variants and post-translational modifications (PTM). Their paper proposed testable hypotheses about cancer variants altering key PTM sites and experimentally tested the hypotheses in EGFR and PKCβ. The article is available here.

Please congratulate TEAM PURPLE for taking the win at the IOB Spring Retreat 2018 Golf Cart Quest!

IOB graduate students publish in the Journal of Biological Chemistry (February 12, 2018):
IOB graduate students Annie Kwon and Ruan Zheng in Dr. Kannan’s lab have recently published a paper in the Journal of Biological Chemistry.  Using a variety of computational and experimental methods, their work uncovered a novel regulatory mechanism that has uniquely evolved in Ephrin kinases. Their paper describes how this mechanism utilizes flexible protein segments flanking each side of the Ephrin kinase domain to cooperatively regulate Ephrin kinase activity. The article is available here: http://www.jbc.org/content/early/2018/02/12/jbc.RA117.001296.abstract.

A BIG congratulations to our graduates!