Dr. Orlando conducts research on using mass spectrometry (MS) to answer biological questions. He also is concerned with developing new methodologies to increase the amount of information obtained from MS experiments and to reduce the quantity of material needed for analysis.
Research Interest
Our research focuses on how differentiated cells become undifferentiated, bypass senscence, undergo immortalization and eventually become transformed. Specifically, we are looking at the role of dominant negative helix loop helix proteins in the initiation and maintenance of prostate cancer, fundamental biology of Id gene/ protein expression, large scale genomic and transcriptomic changes during neoplastic transformation of epithelial cells, and androgen regulated pathways in prostate epithelial cells.
Research Interest
Our research is focused using engineering and microfluidics devices to address questions in neuroscience, cell biology, and biotechnology. We use microfluidic devices because shrinking the devices down to a scale comparable to typical biological systems allows us to gather large-scale quantitative data. Also, these new techniques allow us to examine unique phenomena at the micro and nano length scale, such as enhanced surface effects and transport phenomena.
